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Results for "

DNA polymerase

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    205
    TargetMol | Inhibitors_Agonists
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    TargetMol | Compound_Libraries
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    TargetMol | Inhibitors_Agonists
DNA polymerase-IN-1
T80644809234-33-1In house
DNA polymerase-IN-1, a DNA polymerase inhibitor, exhibited antiproliferative activity against tumor cells with a half-inhibitory concentration (IC50) of 20.7 μM. DNA polymerase-IN-1 inhibited Taq DNA polymerase with an IC50 of less than 250 μM. DNA polymerase-IN-1 was shown to inhibit Taq DNA polymerase by RT- DNA polymerase-IN-1 showed antiretroviral activity in vitro by RT-PCR assay and can be used to study oxidative damage and colorectal cancer.
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8-10 weeks
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ART558
T92752603528-97-6
ART558 is a potent, selective, low molecular weight, allosteric DNA polymerase activity of Polθ inhibitor (IC50=7.9 nM). ART558 can be used for the research of cancer.
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TargetMol | Inhibitor Hot
Vidarabine
Vira-A, Arabinosyladenine, Ara-A, Adenine Arabinoside, 9-β-D-Arabinofuranosyladenine
T15065536-17-4
Vidarabine (Adenine Arabinoside) is a nucleoside antibiotic isolated from Streptomyces antibioticus. It has some antineoplastic properties and has broad spectrum activity against DNA viruses in cell cultures and significant antiviral activity against infections caused by a variety of viruses such as the herpes viruses, the VACCINIA VIRUS and varicella zoster virus.
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3,4-Dihydroxybenzylamine hydrobromide
NSC 263475 hydrobromide
T1010416290-26-9
3,4-Dihydroxybenzylamine hydrobromide (NSC-263475 hydrobromide) inhibits DNA polymerase activity in melanoma cells and displays growth inhibitory activity in melanoma cell lines with varying degrees of tyrosinase activity.
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4-6 weeks
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TargetMol | Inhibitor Sale
Clevudine
L-FMAU, Levovir
T6446163252-36-6
Clevudine (Levovir) is a synthetic pyrimidine analogue with activity against hepatitis B virus (HBV). Intracellularly, clevudine is phosphorylated to its active metabolites, clevudine monophosphate and triphosphate. The triphosphate metabolite competes with thymidine for incorporation into viral DNA, thereby causing DNA chain termination and inhibiting the function of HBV DNA polymerase (reverse transcriptase). Clevudine has a long half-life and shows significant reduction of covalently closed circular DNA (cccDNA), therefore the patient is less likely to have a relapse after treatment is discontinued.
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Neobavaisoflavone
T6S013941060-15-5
1. Neobavaisoflavone is isolated as a DNA polymerase inhibitor. 2. Neobavaisoflavone might be a potential anabolic agent to treat bone loss-associated diseases. 3. Neobavaisoflavone has anti-inflammatory activity, can significantly inhibit the production
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Cholesteryl Hemisuccinate
Cholesterol hydrogen succinate
T675091510-21-0
Cholesteryl Hemisuccinate (Cholesterol hydrogen succinate) is a highly soluble cholesterol analogue often used in polar solutions for its hepatoprotective, anticancer and tumour growth inhibiting properties. Cholesteryl Hemisuccinate inhibits the hepatotoxicity of acetaminophen and prevents AAP-induced apoptosis and necrosis in hepatocytes. Cholesteryl Hemisuccinate inhibits DNA polymerase and DNA topoisomerase, thereby inhibiting DNA replication and repair as well as cell division.
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7-10 days
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DNA polymerase-IN-6
T2042842701561-91-1
DNA polymerase-IN-6 (Compound 27) exhibits inhibitory activity against DNA polymerase, with EC50 values of 0.33 µM for HCMV, 1.9 µM for HSV-1, 0.76 µM for HSV-2, and 0.066 µM for EBV.
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10-14 weeks
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DNA polymerase-IN-2
T79307
DNA polymerase-IN-2 (Compd 3c), a coumarin derivative, inhibits Taq DNA polymerase with an IC50 value of 48.25 μM and shows potential for value-added disease research [1].
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DNA polymerase-IN-3
T79308381689-75-4
DNA polymerase-IN-3 (Compd 5b), a coumarin derivative, inhibits Taq DNA polymerase and shows potential applications in proliferative disease research [1].
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8-10 weeks
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Taq DNA polymerase
T799222304873-37-6
Taq DNA polymerase, a thermostable enzyme, is utilized in polymerase chain reactions (PCR) to amplify DNA sequences [1].
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DNA polymerase-IN-4
T82536
DNA polymerase-IN-4 (Compd 5c), a coumarin derivative, demonstrates antiretroviral activity with an IC50 of 134.22 μM [1].
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DNA polymerase-IN-5
T89367
DNA polymerase-IN-5 (compound 42) is a broad-spectrum antiviral agent effective against herpesviruses. It exhibits inhibitory activity against CMV and VZV with IC50 values of 6.6 μM and 4.8 μM, respectively.
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Resveratrol
trans-Resveratrol, SRT 501
T1558501-36-0
Resveratrol (SRT 501) is a polyphenolic natural product, a plant antitoxin with antioxidant and chemopreventive activities. Resveratrol has a wide range of targets including COX, SIRT, LOC, etc. Resveratrol induces autophagy and apoptosis.
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TargetMol | Inhibitor Hot
aoh1996
T775202089314-64-5In house
AOH1996 is an orally active ligand for the replicasome component PCNA (proliferating cell nuclear antigen), targeting the transcription-replication conflict (TRC). It interferes with the interaction of PCNA with its binding proteins, leading to DNA replication stress and apoptosis. AOH1996 causes proteasome-dependent rpb1 degradation and lethal DNA damage by stabilizing the interaction between PCNA and RNA polymerase II, and acts synergistically with DNA damaging agents to inhibit tumor cell growth.
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7-10 days
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TargetMol | Inhibitor Hot
Galidesivir
BCX4430, Immucillin-A
T10491249503-25-1In house
Galidesivir (BCX4430) is a broad-spectrum antiviral compound, an adenosine analog that inhibits viral RNA-dependent RNA polymerase (RdRp) activity.Galidesivir inhibits a wide range of RNA viral pathogens in vitro, and reduces lung infections in infected animals.
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10-14 weeks
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Apricitabine
AVX754, SPD754
T14313160707-69-7In house
Apricitabine (SPD754) is a highly selective and orally active HIV-1 reverse transcriptase inhibitor (Ki=0.08 μM), the (-) enantiomer of 2′-deoxy-3′-oxy-4′-thiocytidine (dOTC) . Apricitabine inhibits DNA polymerase α, β and γ with Ki values of 300 μM, 12 μM and 112.25 μM, respectively. Apricitabine has shown good antiretroviral therapeutic efficacy in antiretroviral HIV-infected patients, with good tolerability and low selective resistance.
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6-8weeks
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Filibuvir
PF-00868554
T15282877130-28-4In house
Filibuvir (PF-00868554) is a selective and noncovalent inhibitor of HCV NS5B RNA-dependent RNA polymerase. Filibuvir inhibits genotype 1a and 1b replicons with EC50s of 59 nM.
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8-10 weeks
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GS-9191
GS 9191
T25466859209-84-0In house
GS-9191 is a potent inhibitor of DNA polymerase alpha and ß , a prodrug of the novel nucleoside analogue 9-(2-phosphonomethoxyethyl)guanine (PMEG) , which penetrates the skin and is metabolized in the epithelium to an active nucleoside triphosphate analogue.GS-9191 has antiproliferative activity and reduces the size of papillomas in a dose-related manner.GS-9191 may be useful in the treatment of HPV-induced lesions.
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6-8weeks
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TargetMol | Inhibitor Sale
setrobuvir
RO-5466731, RG-7790, RG7790, ANA-598, ANA598
T287621071517-39-9In house
Setrobuvir (ANA-598) is an orally active non-nucleoside HCV NS5B polymerase inhibitor with inhibitory effects on de novo RNA synthesis and primer extension with IC50s between 4 and 5 nM. setrobuvir shows good binding affinity for SARS-CoV-2 RdRp and induces inhibition of RdRp.
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6-8weeks
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Talviraline
Bay 10-8979, HBY 097, Bay10-8979, Bay-108979, Bay108979, Bay 108979, Bay-10-8979
T28918163451-80-7In house
Talviraline (Bay 10-8979) is an RNA-induced DNA polymerase inhibitor.Talviraline is a potent inhibitor of HIV-1-induced cell killing and HIV-1 replication in a variety of human cell lines, as well as in fresh human peripheral blood lymphocytes and macrophages.
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6-8weeks
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IMT1B
3-Piperidinecarboxylic acid, 1-[(2R)-2-[[4-(2-chloro-4-fluorophenyl)-2-oxo-2H-1-benzopyran-7-yl]oxy]-1-oxopropyl]-, (3S)-, LDC203974
T88422304621-06-3In house
IMT1B (LDC203974) is an orally administered, specific noncompetitive allosteric inhibitor of mitochondrial RNA polymerase (POLRMT), effectively suppressing mitochondrial DNA (mtDNA) expression and conferring anti-tumor properties.
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Foscarnet sodium
Phosphonoformate
T022063585-09-1
Foscarnet sodium (Phosphonoformate) is an antiviral agent used in the treatment of cytomegalovirus retinitis. Foscarnet also shows activity against human herpesviruses and HIV.
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Clofarabine
Clofarex, Evoltra, Clolar
T0297123318-82-1
Clofarabine (Clofarex)m, a second generation purine nucleoside analog with antineoplastic activity, inhibits the enzymatic activities of ribonucleotide reductase (IC50 = 65 nM) and DNA polymerase.
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